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Articles from Jerry Carter | Selfgrowth.com
- CD38, a key depletion regulator molecule for CAR-T cells - by Submitted on Mar 29, 2024 from Jerry CarterIn recent years, CAR-T cell therapy has become one of the most promising treatments for hematologic malignancies and autoimmune diseases. The immunosuppressive environment and T-cell dysfunction that CAR-T cells face in vivo are the main factors contributing to suboptimal CAR-T cell therapy. ...
Views: 171 - A new use for type 2 diabetes drug: treating human autoimmune diseases - by Submitted on Jun 25, 2023 from Jerry CarterRecently, a paper titled "Canagliflozin impairs T cell effector function via metabolic suppression in autoimmunity" was published online in the international journal Cell Metabolism by scientists from Swansea University and other institutions. They found that canagliflozin may potentially be ...
Views: 335 - New T-cell vaccine against SARS-CoV-2 mutant strains - by Submitted on Jun 25, 2023 from Jerry CarterA research team from China has developed an mRNA-based T-cell-inducing antigen vaccine that strengthens the COVID-19 vaccine against SARS-CoV-2 variants. Herd immunity through mass vaccination is an effective way to prevent infectious diseases. However, the common SARS-CoV-2 mutant strains ...
Views: 326 - First tRNA delivery via LNP brings new treatment modality for genetic diseases - by Submitted on Jun 25, 2023 from Jerry CarterNonsense mutations, which occur when a sense codon in a protein-coding sequence becomes a premature termination codon (PTC), are responsible for approximately 11% of human genetic diseases. The translational process of mRNA to protein is carried out by tRNA, which recognizes the codon on mRNA ...
Views: 286 - Structural Insights into the G-Protein Specific Recognition Mechanism of the Human Glucagon Receptor - by Submitted on Jun 25, 2023 from Jerry CarterG protein-coupled receptors (GPCRs) play an important role in cellular signaling and serve as important therapeutic targets for a variety of diseases. Upon binding to extracellular agonists, GPCRs stimulate distinct signaling pathways by recruiting different G proteins (Gs, Gi, Gq, etc.,) to ...
Views: 276 - The control of COVID-19 may require regular booster vaccinations - by Submitted on Jun 25, 2023 from Jerry CarterMost people today are immune to SARS-CoV-2, the coronavirus that causes COVID-19, thanks to widespread vaccination campaigns and unplanned infection. Although this widespread immunity hasn't stopped new infections from happening, it has slowed the devastating spread of illness and death that the ...
Views: 311 - A new, efficient protein delivery system may revolutionize gene therapy! - by Submitted on Jun 25, 2023 from Jerry CarterScientists from MIT and the Broad Institute have leveraged an existing bacterial system to create a novel strategy for protein delivery that is effective in both human and animal cells. This technique may be used to target certain cell types for the delivery of a wide range of proteins, ...
Views: 286 - A novel mechanism of natural immune regulation of gamma herpesvirus replication - by Submitted on Apr 28, 2023 from Jerry CarterGamma herpes viruses, including KSHV and EBV, are clinically associated with the development of various malignancies such as Kaposi's sarcoma, primary exudative lymphoma, and nasopharyngeal carcinoma. Gamma herpes viruses have a biphasic life cycle, namely the latent infection phase and the ...
Views: 376 - Nanoflu vaccine protects against seasonal flu - by Submitted on Apr 28, 2023 from Jerry CarterScientists have created a vaccine for experimental use that protects animals from both seasonal and pandemic variants of the influenza virus. Clinical trials of the vaccine are now under development. Next-generation vaccinations for the flu have the potential to replace seasonal choices if they ...
Views: 373 - Create a Vaccine Using a Live Virus! - by Submitted on Apr 28, 2023 from Jerry CarterOn March 23, Professor Tang Ruikang from the Department of Chemistry of Zhejiang University, Associate Researcher Wang Xiaoyu from Qiushi Institute of Advanced Studies, and Researcher Hou Lihua from the Institute of Biological Engineering, Institute of Military Medical Research, Academy of ...
Views: 373 - The fat-causing bacteria found! - by Submitted on Apr 28, 2023 from Jerry CarterObesity and the gut microbiome have both been the focus of recent studies. The term "gut flora" refers to the collection of microorganisms—mostly bacteria—that inhabit the human digestive tract. Fascinatingly, bacteria make up about half of our daily fecal output and have been estimated to ...
Views: 368 - Can coffee protect the liver? - by Submitted on Apr 09, 2023 from Jerry CarterGlobally, around 3 billion cups of coffee are drank daily, according to estimates. Due to its high caffeine concentration, it is frequently used to enhance alertness and productivity. Past research has demonstrated that frequent coffee drinking is associated with a number of health ...
Views: 387 - Another viral cruise in the US! - by Submitted on Apr 09, 2023 from Jerry CarterThere is concern that the United States will be attacked by another "viral cruise ship" following the spread of SARS-CoV-2. While on a sightseeing cruise from February 26th to March 5th, 2019, 284 guests and 34 crew members aboard the Ruby Princess reported feeling unwell. Patients mostly ...
Views: 383 - A Universal Vaccine to Treat Cancer Strikes - by Submitted on Apr 09, 2023 from Jerry CarterCancer is a significant global public health concern. Due to variables such as nutrition, the environment, and the aging of the population, the global prevalence of cancer has increased in recent years, and cancer is gaining prominence as the main cause of death. Chemotherapy, radiation ...
Views: 355 - Unraveling the molecular mechanisms by which intestinal flora metabolites promote the efficacy of pancreatic cancer chemotherapy - by Submitted on Apr 09, 2023 from Jerry CarterBy 2040, pancreatic ductal adenocarcinoma (PDAC) is projected to become the second most fatal kind of cancer in humans, and the majority of patients with PDAC will not respond to chemotherapy according to existing treatment protocols. Scientists have identified diet as an environmental element ...
Views: 508 - PD-1 inhibitors may treat Alzheimer's disease? - by Submitted on Apr 09, 2023 from Jerry CarterAlthough the prevailing view remains that β-amyloid (Aβ) is key in the pathogenesis of AD, and there is considerable research evidence to support this, the progression of AD brain atrophy is associated with the accumulation of only one other pathological marker, tau protein. Recently, a study ...
Views: 353 - A "miracle" fruit that can enhance the immune response to tumors - by Submitted on Mar 06, 2022 from Jerry CarterThe advent of immune checkpoint inhibitors (ICI) has improved the overall survival of patients with a variety of malignancies. However, the problem of drug resistance to ICI therapy (https://immune-checkpoint.creative-biolabs.com/immune-checkpoint-therapy.htm) remains a major obstacle limiting ...
Views: 446 - Gamma delta T cells in tumor immunotherapy - by Submitted on Mar 06, 2022 from Jerry CarterImmunotherapy, in addition to surgery, chemotherapy, and radiotherapy, has now become the fourth pillar of anticancer treatment, with T cell-based immunotherapy being a successful cancer treatment technique. T cells can be separated into two subpopulations based on the expression of T-cell ...
Views: 391 - Closing the "tunnel of cells" to slow cancer - by Submitted on Mar 06, 2022 from Jerry CarterRecent research has uncovered an especially aggressive mechanism for the spread of a particularly aggressive type of breast cancer, in which the NUP93 protein plays a key role. Because this protein creates a "tunnel" in the nuclear membrane ...
Views: 388 - OCD: an "autoimmune disease" - by Submitted on Mar 06, 2022 from Jerry CarterObsessive-compulsive disorder (OCD) is a serious and common psychiatric disorder with a prevalence of approximately 1-3% in adults. The onset of OCD has a bimodal age distribution, usually manifesting first in late childhood and early adolescence and later appearing in early adulthood. OCD is a ...
Views: 565 - Three generations of ADC: Nearly a decade of development-PI - by Submitted on Mar 06, 2022 from Jerry CarterAntibody-drug conjugate (ADC: https://www.creative-biolabs.com/adc/), a compound that connects a cytotoxic small-molecule drug to a monoclonal antibody via a rationally established linker, which selectively delivers an efficient cytotoxic agent into the tumor, has made significant progress in ...
Views: 390 - Too much sugar consumed at a young age can harm the brain and lead to mental disorders - by Submitted on Feb 08, 2022 from Jerry CarterSugar is a direct source of sweetness that not only enhances the flavor of food but also serves as a source of energy for the body. Sugar is used in everyday life to give us a "sweet" feeling, whether it's in candy, cake, or cola. Sugar consumption is quickly increasing as material living ...
Views: 374 - New Naming Rules for Antibodies: Dropping the "-mAb" Stem - by Submitted on Feb 07, 2022 from Jerry CarterA review paper was published in the journal Nature Reviews Drug Discovery on January 13, 2022: Despite the fact that the familiar "-mab" has retired, it marks a new era in antibody drug development. In November 2021, the WHO updated the generic naming rule for antibody drugs, three years ...
Views: 602 - New discovery! The "dual personality" protein is both a "firewall" against cancer and a "promoter" of cancer! - by Submitted on Feb 07, 2022 from Jerry Carter"Coordinated post-transcriptional modulation of oncogene-induced senescence by UNR/CSDE1," according to a study published in Cell Reports (Jan. 11), shows an important molecular mechanism that underpins the body's natural protection against skin cancer development. This study sheds fresh light ...
Views: 401 - Immune Checkpoint Inhibitors: Where Do They Go From Here? - by Submitted on Feb 07, 2022 from Jerry CarterThe use of immune checkpoint inhibitors (ICIs) has become the most important achievement in oncology in the last decade. From a more holistic viewpoint, it is a powerful clinical strategy. Cancer cells are transformed from normal cells, and through altering the tumor immune milieu, the ...
Views: 435 - Putting the gas on the immune system! - by Submitted on Feb 07, 2022 from Jerry Carter"Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity", published by a team of researchers from the Massachusetts Institute of Technology (MIT) in Nature Biomedical Engineering on January 10, 2022. Attacking tumors by stimulating the ...
Views: 351 - Intestinal optogenetics elucidates the neurobiological mechanism of sucrose preference in the intestine - by Submitted on Feb 07, 2022 from Jerry CarterSweet sensations can be induced by both sucrose and artificial sweeteners, but animals and humans prefer the former. Even mice without taste receptors are able to distinguish between sucrose and sweets. Although the tongue is responsible for sweetness perception, the duodenum is crucial in ...
Views: 775 - Improved Gene Editing Technology for Stem Cell Study! - by Submitted on Feb 07, 2022 from Jerry CarterResearchers at the University of Helsinki have devised a new technique for returning human cells to a stem cell state that is faster and more reliable. Pluripotent stem cells, which can differentiate into any cell in the body and can generate all tissues and organs, are the present focus of ...
Views: 419 - A "bad" bacteria in colon cancer may serve a "positive" role in tumor immunity - by Submitted on Jan 04, 2022 from Jerry CarterImmunotherapy (https://www.creative-biolabs.com/immuno-oncology/) has been successfully applied clinically to treat a wide range of hematological and solid metastatic malignancies. The most widely used drugs targeting immune checkpoints, such as programmed cell death protein 1 (PD-1) and its ...
Views: 369 - Scientists mapped glycosylation patterns associated with the onset of Alzheimer's disease in humans - by Submitted on Jan 04, 2022 from Jerry CarterN-chain protein glycosylation in the brain is an understudied aspect of glucose utilization that affects a variety of cellular processes, including resting membrane potential, axonal activation, and synaptic vesicle transport. In a recent study published in the journal Alzheimer's & DementiaIn ...
Views: 507 - New Cell study uncovers why mRNA vaccines are so effective against COVID-19 - by Submitted on Jan 04, 2022 from Jerry CarterThe haze of the COVID-19 epidemic still hangs over human society and has yet to subside. As the northern hemisphere enters the cold season and a new mutant strain of Omicron emerges, a new wave of neo-crown epidemics seems to be emerging. Since the approval of the first vaccine in early 2020, ...
Views: 428 - Status of NKG2A-targeting drugs under research—PART I - by Submitted on Jan 04, 2022 from Jerry CarterNKG2A (NK cell lectin-like receptor subfamily C member 1) Molecular Alias: NKG2A (https://www.creative-biolabs.com/magic-antibody-discovery-human-nkg2a-cd159a-94-233-membrane-protein-partial-his-tag-4490.htm), CD159a, KLRC1, NK cell receptor A Background: NKG2A/B/C/D/E/F are members of the ...
Views: 387 - Viagra may help to prevent Alzheimer's disease - by Submitted on Jan 03, 2022 from Jerry CarterThe most common neurodegenerative disease is Alzheimer's disease (AD), often known as dementia. The loss of memory, learning ability, emotional regulation, and athletic ability is common in patients, all of which have a negative impact on health, families, and society. Currently, about 50 ...
Views: 521 - Anthrax toxin, lethal, but can be used to relieve pain - by Submitted on Jan 03, 2022 from Jerry CarterPain receptors are a type of sensory neuron (https://neuros.creative-biolabs.com/foundations-of-neurosciences.htm) that alerts us to potentially harmful environmental changes or stimuli, such as extreme heat or stress. Their signals are converted into pain feelings in the brain. Specific forms ...
Views: 396 - Another PROTAC entered clinical study - by Submitted on Jan 03, 2022 from Jerry CarterDecember 24, 2021—Accutar Biotechnology, a biotechnology company focused on AI drug development, announced that the FDA has approved its IND for AC0176 for the treatment of patients with metastatic decompensated refractory prostate cancer (mCRPC). AC0176 is an orally administered chimeric ...
Views: 338 - Firstly Uncovered Genetic Clues to Schizophrenia - by Submitted on Jan 03, 2022 from Jerry CarterCornel University researchers recently made a breakthrough in the study of schizophrenia with human-derived cerebral organoids. Schizophrenia is a chronic brain disorder of hitherto unknown exact etiology, with typical symptoms usually appearing in early adulthood and affecting approximately ...
Views: 308 - What is the severity of the Omicron mutation? - by Submitted on Jan 03, 2022 from Jerry CarterRecently, many scientists around the world summarized what they have learned about Omicron (an emerging variant of SARS-CoV-2) so far, as reported in Nature. Researchers from all over the world are now studying the Omicron strain to learn more about its infectivity, pathogenicity, and immune ...
Views: 357 - PROTAC technology, a powerful tool for innovative drug development—Advantages - by Submitted on Oct 06, 2021 from Jerry CarterCraig Crews et al. presented the notion of PROTAC (Proteolysis Targeting Chimera: https://www.creative-biolabs.com/protac/) in 2001 to reduce protein levels instead of blocking protein function by exploiting the body's naturally occurring protein cleanup system to treat disease. PROTAC ...
Views: 386 - Uncovering the mystery of the origin of Alzheimer's disease: Is the replication of prions in the human brain the culprit? - by Submitted on Oct 06, 2021 from Jerry CarterIn 1958, Francis Crick proposed the famous "Central Dogma", thereby constructing a large framework for the transmission of biological genetic information, namely "DNA→RNA→Protein". Of course, as a theory, the central principle is often questioned and misunderstood, e.g., RNA can also be written ...
Views: 344 - Another zoonotic virus! One case of death from Nipah virus infection in southern India - by Submitted on Oct 06, 2021 from Jerry CarterAccording to the Associated Press, India's southern state of Kerala is rapidly ramping up efforts to halt an outbreak of the deadly Nipah virus, despite the fact that the state is currently battling SARS-CoV-2 that poses a greater threat. Kerala was put on high alert when a 12-year-old boy ...
Views: 372 - The first approved DNA vaccine against SARS-CoV-2—ZyCoV-D - by Submitted on Oct 06, 2021 from Jerry CarterRecently, India approved a new COVID-19 vaccine, ZyCoV-D, which uses a circular DNA strand to stimulate the immune system against the SARS-CoV-2. The approval of ZyCoV-D as the world's first DNA vaccine for humans heralds the arrival of DNA vaccines against various diseases. According to ...
Views: 387 - Uncovering the mystery of the origin of Alzheimer's disease: Is the replication of prions in the human brain the culprit? - by Submitted on Oct 06, 2021 from Jerry CarterIn 1958, Francis Crick proposed the famous "Central Dogma", thereby constructing a large framework for the transmission of biological genetic information, namely "DNA→RNA→Protein". Of course, as a theory, the central principle is often questioned and misunderstood, e.g., RNA can also be written ...
Views: 367 - Say goodbye to injections, magnetic insulin capsules with magnetic positioning are introduced - by Submitted on Oct 06, 2021 from Jerry CarterInsulin injections are currently one of the most popular diabetes treatment options, particularly for persons with type 1 diabetes who require daily insulin injections to keep their blood sugar levels under control. Researchers have claimed to have invented an implantable intraperitoneal ...
Views: 366 - Moderna launched a clinical study for an HIV mRNA vaccine in - by Submitted on Oct 06, 2021 from Jerry CarterModerna launched a clinical study for an HIV mRNA vaccine in August 2021, on 56 HIV-negative people aged 18 to 50. AIDS is a highly contagious disease. In 2020, the United Nations estimates that 37.7 million people would be living with HIV around the world. However, there is currently no ...
Views: 395 - Cancer Cell: Barrier to cancer immunotherapy discovered - by Submitted on Oct 04, 2021 from Jerry CarterStanniocalcin-1 (STC1) is a glycoprotein hormone(https://www.creative-biolabs.com/glycoprotein/) involved in calcium/phosphate homeostasis that regulates a variety of cellular processes during normal development and tumorigenesis. After analyzing more than 1,000 genes, researchers at the ...
Views: 638 - Cancer Immunotherapy Overview - by Submitted on Oct 04, 2021 from Jerry CarterIn the Journal of Controlled Release, Vol. 336, 2021, Islam A. Khalil's research group from the Misr University for Science and Technology (Egypt) published a review article titled "Cancer immunotherapy from biology to nanomedicine." Cancer is one of the most common causes of mortality in ...
Views: 418 - The 12th ADC Drug Approved by the FDA - by Submitted on Oct 04, 2021 from Jerry CarterSeagne and Genmab announced on September 20, 2021 that Tisotumab Vedotin has received accelerated approval from the FDA for the treatment of recurring or metastatic cervical cancer. Tivdak (Tisotumab vedotin-tftv) is an ADC produced by combining Genmab's tissue factor (TF) monoclonal antibody ...
Views: 414 - A major breakthrough has occurred! 99.9% safe contraceptive antibodies are now available - by Submitted on Oct 04, 2021 from Jerry CarterUnplanned pregnancy has always been a source of frustration, and researchers have worked diligently to create a range of contraceptive techniques. There are several types of contraception available for women, which may be described as hormonal contraception and barrier contraception. * ...
Views: 353 - The endocytosis mechanism of ADC drugs: Part II - by Submitted on Oct 04, 2021 from Jerry CarterPit-mediated endocytosis Clathrin-independent endocytosis includes caveolin-mediated endocytosis, caveolin-independent carrier protein/GPI-enriched early inner compartment (CLIC/GEEC), and macropinocytosis. The pit is a vial-like invagination of the plasma membrane, characterized by high ...
Views: 352 - NEJM: Decreased protection efficiency of mRNA and adenovirus vaccines against delta mutant - by Submitted on Sep 06, 2021 from Jerry CarterOn August 12, 2021, data on the efficiency of real-world vaccine protection in the United Kingdom was published in the New England Journal of Medicine (NEJM). Since the global outbreak of the COVID-19 epidemic in early 2020, various mutant strains have continued to emerge, including Alpha ...
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