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Articles from Thomas Schmitt | Selfgrowth.com
- How to Calculate the Volume, Mass, and Concentration of Gold Nanoparticle - by Submitted on Jul 28, 2024 from Thomas SchmittGold is a chemically stable metal with a molar mass of 196.96657 g/m and a density of 19.3 g/cm3. It is often used for decoration and money, but its properties change strangely when its size shrinks to the nanometer level. Gold nanoparticles have special physical and chemical properties ...
Views: 42 - Application of Nanoparticles in CRISPR/Cas9 Gene Therapy - by Submitted on Jul 26, 2024 from Thomas SchmittAt present, genetic diseases are a large category of diseases that affect human health. So far, we can only treat a small part of them, and most of the treatment methods are "treating the symptoms but not the root cause". Therefore, gene therapy that can "cure the root cause" is highly ...
Views: 41 - The Role of Vitamin D in Anti-tumor I - by Submitted on Jul 26, 2024 from Thomas SchmittVitamin D is a fat-soluble vitamin that can be obtained from food. At the same time, cholesterol in the body can be oxidized to 7-deoxycholesterol, which is converted into vitamin D by ultraviolet radiation. It is the precursor of a powerful steroid hormone. It synthesizes biologically active ...
Views: 47 - Research Progress on the Immune Mechanism of Varicella-Zoster Virus - by Submitted on Jul 25, 2024 from Thomas SchmittVaricella-zoster virus (VZV) is a pathogen widely present in the global population, infecting more than 90% of the world’s population. VZV primary infection often occurs in childhood, which can cause chickenpox characterized by systemic vesicular eruptions, and after infection, it can remain ...
Views: 44 - Reprogramming of Lipid Metabolism in the Tumor Microenvironment - by Submitted on Jul 25, 2024 from Thomas SchmittReprogramming of lipid metabolism has become an important feature of cancer. In order to adapt to the hypoxic and nutrient-deficient microenvironment, tumor cells, in addition to increasing glucose uptake and aerobic glycolysis, also need to undergo lipid metabolism reprogramming to enhance ...
Views: 43 - Illuminating Possibilities Unveiling the Power of Fluorescent Polystyrene Particles in Biosensing Applications - by Submitted on Jun 28, 2024 from Thomas SchmittA biosensor is a device that measures a biological or chemical reaction by producing a signal that is proportional to the concentration of the analyte in the reaction. Biosensors are used in disease monitoring, drug development, and detection of pollutants, pathogenic microorganisms, and ...
Views: 67 - mRNA Nanocarriers - by Submitted on Jun 28, 2024 from Thomas SchmittAs an intermediate carrier, mRNA can transfer the genetic code in DNA to ribosomes for protein expression. It has great potential in vaccines, protein replacement therapy, and gene editing. Compared with traditional small molecule and protein drugs, mRNA-based therapies show some specific ...
Views: 63 - Reprogramming of Lipid Metabolism in the Tumor Microenvironment - by Submitted on Jun 28, 2024 from Thomas SchmittReprogramming of lipid metabolism has become an important feature of cancer. In order to adapt to the hypoxic and nutrient-deficient microenvironment, tumor cells, in addition to increasing glucose uptake and aerobic glycolysis, also need to undergo lipid metabolism reprogramming to enhance ...
Views: 62 - Autoimmune Diseases and Their Detection - by Submitted on Jun 28, 2024 from Thomas SchmittAutoimmune diseases are diseases caused by an autoimmune response. The role of the human immune system is to protect the body from pathogenic microorganisms and cancer cells. When the immune system accidentally attacks your body instead of protecting it, it will cause damage or dysfunction of ...
Views: 61 - Adeno-Associated Virus Vector (AAV) Application Q&A - by Submitted on May 29, 2024 from Thomas SchmittAdeno-associated virus (AAV), as an important gene delivery and expression tool, has been widely used in the fields of scientific research and gene therapy in recent years. As a gene delivery system, AAV viral vectors have the advantages of good safety, low immunogenicity, the ability to infect ...
Views: 87 - Why the Desired Effect is not Achieved After Using AAV? - by Submitted on May 29, 2024 from Thomas SchmittAdeno-associated virus (AAV) is a small non-enveloped virus, belonging to the family Parvoviridae. It was first discovered in 1965 from contaminants of adenovirus isolates. It has an icosahedral structure on the outside and a diameter of about 26 nm. Its capsid protein is composed of It is ...
Views: 75 - Microfluidics Revolution: Polystyrene Particles Powering Miniaturized and Automated Immunoassays - by Submitted on May 29, 2024 from Thomas SchmittTraditional immunoassays based on the format of 96-well microtiter plates are widely used in analytical laboratories and have become increasingly automated with the introduction of robotics technology in recent years, thereby enhancing assay throughput. Most clinical analyzers essentially ...
Views: 79 - The Mechanism of Adverse Immune Reactions of LNP-mRNA - by Submitted on May 29, 2024 from Thomas SchmittMany clinical trials of mRNA-based drugs or vaccines have failed to successfully pass Phase I or Phase II. The reasons behind this are various, including low efficacy of candidate drugs and lower-than-expected clinical risk/treatment benefit profiles. Preclinical safety assessments aim to ...
Views: 83 - PLGA Nano Drug Carrier - by Submitted on Apr 25, 2024 from Thomas SchmittPoly(lactic-co-glycolic acid) (PLGA) is a functional polymer organic compound randomly polymerized by lactic acid (PLA) and glycolic acid (PGA). It has been approved by the U.S. Food and Drug Administration It is certified by the Food and Drug Administration (FDA) and is a copolymer material ...
Views: 99 - Colored Polystyrene Particles in Developing Rapid and Affordable Point-of-Care Diagnostics - by Submitted on Apr 25, 2024 from Thomas SchmittPOCT (Point-of-Care Testing) refers to clinical and bedside testing conducted in close proximity to patients. It is often not performed by clinical laboratory personnel. POCT holds significant importance in disease prevention, etiology determination, prognosis, enhancing treatment outcomes, and ...
Views: 93 - Testing for Respiratory Syncytial Virus - by Submitted on Apr 25, 2024 from Thomas SchmittRespiratory syncytial virus was isolated from the cold-like respiratory tract of chimpanzees in 1956. It is called respiratory syncytial virus because it causes the fusion of adjacent cells during cell culture and the formation of syncytial-like structures in the cells. According to different ...
Views: 91 - Research on Snake Venom Detection Methods - by Submitted on Apr 25, 2024 from Thomas SchmittSnake bites seriously threaten public health security in tropical and subtropical countries and regions. Due to the high mortality and disability rates caused by venomous snake bites, there are an estimated 1.8 to 2.7 million snake bites worldwide each year, with 81,000 to 138,000 related ...
Views: 98 - Progress in the Development of Targeted Anti-Tumor Antibody-Drug Conjugates - by Submitted on Mar 27, 2024 from Thomas SchmittAntibody-drug conjugates (ADCs) are conjugated products of monoclonal antibodies (mAbs) and cytotoxic small molecules. In tumor treatment, although monoclonal antibodies have good targeting properties, most of them target extracellular or cell surface antigens, have weak anti-tumor activity, ...
Views: 130 - Exploring Dyed Polystyrene Latex Particles Enhancing Immunoassays and Beyond - by Submitted on Mar 27, 2024 from Thomas SchmittWhat are Dyed Polystyrene Latex Particles? Polystyrene particles (PSP) are commercially available in different sizes, ranging from 15 nanometers to several micrometers, with narrow size distributions and various surface chemistries. Additionally, polystyrene is generally considered inert and ...
Views: 129 - What is Procalcitonin (PCT)? - by Submitted on Mar 27, 2024 from Thomas SchmittProcalcitonin (PCT) is the propeptide of calcitonin. The production of procalcitonin during infection and sepsis does not depend on calcitonin levels, but is closely related to the release of endotoxin and inflammatory mediators in bacterial infection. Traditional biological markers, clinical ...
Views: 127 - Research on the Biological Effects of GLP-2 - by Submitted on Mar 27, 2024 from Thomas SchmittGLP-2 (glucagon-likepeptide-2) was discovered and named by the Lilly Laboratory in the United States when cloning the proglucagon gene (PG). In 1996, Drucker et al. discovered that the active ingredient in proglucagon-derived peptide (PGDP) that promotes intestinal mucosal growth is GLP-2. Its ...
Views: 125 - Zeta Potential: A Fundamental Measure for Colloidal Behavior - by Submitted on Feb 27, 2024 from Thomas SchmittZeta potential (ZP) is a physical property exhibited by any particle in a suspension, macromolecule or material surface. ZP is an analytical technique used to determine the surface charge of nanoparticles in colloidal solutions. The surface of a charged particle attracts and binds firmly to a ...
Views: 132 - Research on the Application of Nanoformulation in Transdermal Drug Delivery System - by Submitted on Feb 27, 2024 from Thomas SchmittAs a promising systemic drug delivery method, transdermal drug delivery system (TDDS) is easier and more convenient to operate than traditional oral, intravenous and subcutaneous injection methods. It can improve patient compliance while also avoiding First-pass effect and drug side effects. As ...
Views: 136 - Research on Genetically Engineered Drug Host Cell Proteins - by Submitted on Feb 27, 2024 from Thomas SchmittGenetically engineered drugs are introduced into host cells such as Escherichia coli, yeast or mammalian cells through recombinant technology to construct engineering strains or cell strains, and then undergo specific expression, assembly, folding and post-translational modification processes to ...
Views: 126 - Effects of Glucagon-Like Peptide-1 Receptor Agonists on Diabetic Cardiomyopathy - by Submitted on Feb 27, 2024 from Thomas SchmittThe incidence and prevalence of diabetes are increasing year by year globally, and patients with diabetes are at increased risk of cardiovascular disease and heart failure. Diabetic cardiomyopathy (DCM) refers to the presence of abnormal myocardial structure and performance in the absence of ...
Views: 124 - Illuminating the World of Plasmonic Nanoparticles: Unveiling the Mystery of Plasmons - by Submitted on Jan 23, 2024 from Thomas SchmittSurface plasmon resonance (SPR) and surface-enhanced Raman scattering (SERS) are two key surface plasmon technologies that ultimately enable single-molecule-level chemical and biological sensors. Due to the tremendous progress in solution-based synthesis methods, plasmonic nanoparticles with ...
Views: 137 - Micelle vs Liposome - by Submitted on Jan 23, 2024 from Thomas SchmittMicelles refer to molecularly ordered aggregates that begin to form in large quantities after the surfactant concentration reaches a certain value in an aqueous solution. In micelles, the hydrophobic groups of surfactant molecules aggregate to form the core of the micelle, and the hydrophilic ...
Views: 138 - Alzheimer's Disease Diagnostic Markers - by Submitted on Jan 23, 2024 from Thomas SchmittAlzheimer's disease (AD) is a progressive neurodegenerative disease with an insidious onset. Clinically, it is characterized by comprehensive dementia manifestations such as memory impairment, aphasia, apraxia, agnosia, impairment of visuospatial skills, executive dysfunction, and personality ...
Views: 140 - What is Herpes Simplex Virus? - by Submitted on Jan 23, 2024 from Thomas SchmittHerpes simplex virus (HSV) belongs to the herpesvirus alpha subfamily and has a unique 4-layer structure. The core of HSV is a linear double-stranded DNA of about 152 000 bp, surrounded by an icosahedral capsid. The outer capsid is a membrane, which contains more than 20 important proteins that ...
Views: 117 - Application of 3D Printing Bioinks Tissue Repair and Regenerative Medicine - by Submitted on Dec 26, 2023 from Thomas SchmittIntroduction to 3D Printing In the 1980s, American engineer Charles Hull developed rapid prototyping technology by combining points and surfaces and then using light reinforcement. After numerous failures, he finally invented stereolithography technology. Based on this technology, the world’s ...
Views: 167 - What You Have to Know about Magnetic-activated Cell Sorting - by Submitted on Dec 26, 2023 from Thomas SchmittMagnetic-activated cell sorting (MACS) is a highly specific cell sorting technique that integrates immunology, cell biology, and magnetic mechanics. Its high specificity comes from the specific recognition of antibody antigens. MACS technology has become the standard method of cell sorting, from ...
Views: 152 - The Role of Targeting p53 Signaling Pathway in Cancer Therapy - by Submitted on Dec 26, 2023 from Thomas SchmittAs a tumor suppressor, p53 is one of the most commonly mutated genes in human cancers. Due to its important role in tumor suppression, p53 has attracted great interest from researchers in drug development. As a transcription factor, p53 is directly or indirectly involved in regulating many ...
Views: 126 - The Role of CXCR5/CXCL13 Axis in Tumors - by Submitted on Dec 26, 2023 from Thomas SchmittThe tumor microenvironment is composed of tumor cells and non-tumor cells (including fibroblasts, vascular and lymphatic endothelial cells, various immune cells) and extracellular components (such as extracellular matrix, cytokines, inflammatory factors, chemokines, etc.) in tumor tissues. ...
Views: 146 - Lipid Nanomedicine Delivery In Vivo - by Submitted on Nov 27, 2023 from Thomas SchmittIn the past few decades, the advent of lipid-based nano-delivery systems has brought research in the field of nanomedicines to new heights. Nanocarriers can encapsulate different types of drug molecules and have the advantages of improving drug solubility, extending circulation, achieving ...
Views: 142 - Gold Nanoparticles in Medicine: A Tiny Marvel with Big Potential - by Submitted on Nov 27, 2023 from Thomas SchmittWith the continuous development of nanotechnology, gold nanoparticles are widely used in the field of medicine. Gold nanoparticles not only have good controllability, biocompatibility, and biosorption, but also have a high degree of stability, and can achieve specific biometrics and functions ...
Views: 180 - Staphylococcus Aureus Enterotoxin B Detection Method - by Submitted on Nov 27, 2023 from Thomas SchmittStaphylococcus aureus (S. aureus) is an important class of food-borne pathogens that cause food contamination and food poisoning, and is also a symbiont of human skin and mucous membranes. Studies have found that about 20%~30 % of healthy individuals carry Staphylococcus aureus. Animal foods are ...
Views: 146 - Research on Capsular Polysaccharide Protein Conjugate Vaccine of Streptococcus Pneumoniae - by Submitted on Nov 27, 2023 from Thomas SchmittStreptococcus pneumoniae is a class of Gram-positive pathogenic bacteria that was first isolated in 1881. The chemical composition of the mucus layer on the surface of Streptococcus pneumoniae is a polysaccharide capsule, which is the main pathogenic substance of Streptococcus pneumoniae and has ...
Views: 177 - What is Nano Dressing? - by Submitted on Oct 30, 2023 from Thomas SchmittNanotechnology has not only received attention and applications in the field of drug delivery, but also has achieved many successes in the field of tissue engineering. Nano dressings can be defined as dressings in which nanomaterials are the matrix. The birth of nano dressings has brought new ...
Views: 203 - What Are PMMA Micro- and Nanoparticles? - by Submitted on Oct 30, 2023 from Thomas SchmittPoly(methyl methacrylate) (PMMA) micro- and nanoparticles are highly spherical, optically clear, and can be dissolved with solvents. These PMMA particles are hydrophilic, transparent, amorphous and colorless thermoplastics that are featured with excellent UV resistance. What is PMMA used ...
Views: 187 - Type 1 Diabetes Autoantibody Research - by Submitted on Oct 30, 2023 from Thomas SchmittType 1 diabetes (T1DM) is an autoimmune disease caused by the destruction of beta cells first, leading to the destruction of related pancreatic islet function. In patients with this disease, generally their humoral immunity and cellular immunity cannot work normally. Humoral immunity is ...
Views: 194 - Type 1 Diabetes Autoantibody Diagnosis - by Submitted on Oct 30, 2023 from Thomas SchmittType 1 diabetes (T1DM) is an autoimmune disease caused by the destruction of beta cells, leading to the destruction of related pancreatic islet functions. In patients with this disease, both humoral and cellular immunity generally do not work properly. Among them, humoral immunity is mainly ...
Views: 156 - Natural Nanocarriers for Delivery Protein Drug - by Submitted on Sep 20, 2023 from Thomas SchmittProtein accounts for 18-20% of the total mass of the human body and is the main carrier of human life activity. Protein has a range of complex functions in the organism, and many human diseases are closely related to the functional regulation of protein. For example, Parkinson’s disease (PD). It ...
Views: 177 - Mastering Colloidal Gold Handling, Storage, and Applications - by Submitted on Sep 20, 2023 from Thomas SchmittColloidal gold is a certain-size gold particle synthesized by gold ion reduction and polymerization of chloroauric acid (HAuCl4) under the action of reducing agents such as white phosphorus, ascorbic acid, sodium citrate, tannic acid, and so on. Due to electrostatic action, gold particles repel ...
Views: 192 - The Relationship Between Gangliosides and Nervous System Development - by Submitted on Sep 20, 2023 from Thomas SchmittGangliosides (GA) are a class of glycosphingolipids (GSLs) containing sialic acid, which are widely distributed in tissues and body fluids, and are most abundant in the nervous system, where their expression accounts for 10 % ~ 12% of the total lipids in nerve cell membranes. Gangliosides ...
Views: 189 - What is the role of TRIM11 in tumors? - by Submitted on Sep 20, 2023 from Thomas SchmittTripartite-motif Protein Family (TRIM) TRIM is composed of more than 80 proteins with E3 ubiquitin ligase activity. According to the different structures of TRIM proteins, they are divided into 11 subfamilies (C-I-C-Ⅺ), of which the C-Ⅳ subfamily has the most members, including 33 TRIMs ...
Views: 183 - What Is Polylactide? - by Submitted on Aug 18, 2023 from Thomas SchmittPolylactide (PLA), also the polylactic acid, is the biodegradable hydrolyzable aliphatic semicrystalline polyester that can be produced through the direct condensation reaction of its monomer, lactic acid, as the oligomer, and also by a ring-opening polymerization of the cyclic lactide ...
Views: 218 - Advances in Research on Iron Oxide Nanoparticles to Amplify Tumor Imaging Signals - by Submitted on Aug 18, 2023 from Thomas SchmittIron oxide nanoparticles have high stability, good dispersion, simple preparation and good biocompatibility. They have shown a wide range of application prospects in the fields of sensor detection, disease diagnosis, gene therapy vectors, and targeted drug delivery. Recently, a research team has ...
Views: 209 - Can PIVKA-II be Used in Liver Cell Cancer Research? - by Submitted on Aug 18, 2023 from Thomas SchmittHepatocellular cancer (HCC) is a clinically common malignant tumor of the digestive tract, which is seriously harmful to human health, and according to the survey, liver cancer accounts for the fifth largest incidence of tumors worldwide and the third mortality rate. At present, liver cancer in ...
Views: 213 - Is Aspartame Safe? - by Submitted on Aug 18, 2023 from Thomas SchmittAspartame is an artificial dipeptide sweetener, which is synthesized from L-phenylalanine and aspartic acid, and its scientific name is L-aspartic acid-L-phenylalanine methyl ester. It is a white crystalline powder that can be hydrolyzed into aspartic acid and phenylalanine in the body acid, ...
Views: 217 - What is a Micro Needle Array Based on Nanomaterials? - by Submitted on Jul 16, 2023 from Thomas SchmittMicro needle (MN) is a micro needle-shaped structure, the length of 100 ~ 1000μm, the bottom diameter of several hundred micrometers, the tip diameter is less than a few dozen micrometer, usually in the form of micro- needle array sticker, can penetrate the skin surface cortex to form ...
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